Understanding Mechanisms of Sex Programming of Cardiovascular Development

Grant number: DP160102404 | Funding period: 2016 - 2019

Completed

Abstract

The goal of this project is to track the influence of sex and sex hormones through crucial lifespan timepoints to define how specific patterns of gene signalling determine adult cardiovascular traits at cell, tissue and systems level. Sexually distinct cardiovascular traits are conserved across mammalian species. Early developmental events are known to be important in influencing later adult characteristics, but how adult cardiovascular functions are ‘programmed’ differently for males and females is not understood. The project aims to uncover the importance of the placenta in regulating foetus exposure to sex steroids and the crucial effects of the pubertal hormone surge in shaping cardiovas..

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Related publications (7)

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Male and female atria exhibit distinct acute electrophysiological responses to sex steroids

SP Wells, C O'Shea, S Hayes, KL Weeks, P Kirchhof, LMD Delbridge, D Pavlovic, JR Bell

2024-09-01

The electrophysiological properties of the hearts of women and men are different. These differences are at least partly mediated b..

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Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats

SP Wells, AJA Raaijmakers, CL Curl, C O'Shea, S Hayes, KM Mellor, JM Kalman, P Kirchhof, D Pavlovic, LMD Delbridge, JR Bell

2023-11-06

Transmural action potential duration differences and transmural conduction gradients aid the synchronization of left ventricular r..

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Myocardial Energy Stress, Autophagy Induction, and Cardiomyocyte Functional Responses

LJ Daniels, U Varma, M Annandale, E Chan, KM Mellor, LMD Delbridge

2019-08-20

Significance: Energy stress in the myocardium occurs in a variety of acute and chronic pathophysiological contexts, including isch..

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Impact of estrogens on the regulation of white, beige, and brown adipose tissue depots

GB Bernasochi, JR Bell, ER Simpson, LMD Delbridge, WC Boon

2019-04-01

As adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) ..

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Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots

Gabriel B Bernasochi, James R Bell, Evan R Simpson, Lea MD Delbridge, Wah Chin Boon

2019-04-01

<jats:title>ABSTRACT</jats:title> <jats:p> As adipose tissue depots are active endocrine org..

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Cardiomyocyte functional screening: Interrogating comparative electrophysiology of high-throughput model cell systems

SP Wells, HM Waddell, CB Sim, SY Lim, GB Bernasochi, D Pavlovic, P Kirchhof, ER Porrello, LMD Delbridge, JR Bell

2019-01-01

Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel antiarrhythmic..

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Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?

GB Bernasochi, WC Boon, CL Curl, U Varma, S Pepe, M Tare, LJ Parry, E Dimitriadis, SB Harrap, CJ Nalliah, JM Kalman, LMD Delbridge, JR Bell

2017-10-01

A correlation exists between the extent of pericardial adipose and atrial fibrillation (AF) risk, though the underlying mechanisms..

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